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143634

Sigma-Aldrich

p-Tolyl isocyanate

99%

Synonym(s):

4-Methylphenyl isocyanate

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About This Item

Linear Formula:
CH3C6H4NCO
CAS Number:
622-58-2
Molecular Weight:
133.15
Beilstein:
471494
EC Number:
210-743-4
MDL number:
MFCD00002029
UNSPSC Code:
12352100
PubChem Substance ID:
24848599
NACRES:
NA.22

Assay

99%

form

liquid

refractive index

n20/D 1.531 (lit.)

bp

70-72 °C/10 mmHg (lit.)

density

1.056 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

Cc1ccc(cc1)N=C=O

InChI

1S/C8H7NO/c1-7-2-4-8(5-3-7)9-6-10/h2-5H,1H3

InChI key

MGYGFNQQGAQEON-UHFFFAOYSA-N

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General description

p-Tolyl isocyanate reacts with human serum albumin to form antigen which helps in detecting IgE antibodies in workers hypersensitive to toluene diisocyanate.

Application

p-Tolyl isocyanate was used to study the catalytic role of supported Rhodium(I) complex toward the reductive carbonylation of nitrobenzene in DMF medium.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1C - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

150.8 °F - closed cup

Flash Point(C)

66 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Catalytic Activity of Supported Rhodium (I) Complex for the Carbonylation of Nitrobenzene: Mechanism for Carbamate Formation.
Kim JH, et al.
Bull. Korean Chem. Soc., 31(6), 1621-1627 (2010)
Johannes Lenz et al.
Polymers, 11(8) (2019-07-31)
A series of new flame retardants (FR) based on dibenzo[d,f][1,3,2]dioxaphosphepine 6-oxide (BPPO) incorporating acrylates and benzoquinone were developed previously. In this study, we examine the fire behavior of the new flame retardants in polyisocyanurate (PIR) foams. The foam characteristics, thermal
K S Tse et al.
Allergy, 40(5), 314-320 (1985-07-01)
The prevalence of sensitization was studied in a group of 76 foundry workers with occupational exposure to diphenylmethane diisocyanate (MDI). Ten workers had clinical evidence of asthma, 40 had non-asthmatic respiratory symptoms, and 26 were asymptomatic. Specific IgE antibodies to
B T Butcher et al.
The Journal of allergy and clinical immunology, 70(4), 231-235 (1982-10-01)
Toluene diisocyanate (TDI) sensitivity accompanied by nonspecific bronchial hyperresponsiveness occurs in approximately 5% of occupationally exposed workers. We report the case of a 32-yr-old worker followed longitudinally after removal from isocyanate exposure. TDI reactivity was lost 11 mo after removal
K C Chang et al.
Clinical allergy, 14(4), 329-339 (1984-07-01)
A worker developed two episodes of severe asthma 90 min after cutting a polyurethane plate made of diphenylmethane diisocyanate (MDI) using a rapidly turning carbide blade. Intradermal skin testing with MDI-human serum albumin (MDI-HSA) and p-tolyl isocyanate-HSA (p-TMI-HSA) were positive
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