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Merck

Increasing the chances for platinum-sensitive ovarian cancer patients.

Future oncology (London, England) (2013-11-15)
Antonio González
ABSTRACT

Ovarian carcinoma is still one of the most common causes of death from cancer in the western world. Despite high sensitivity to chemotherapy, the majority of patients will relapse within 3 years. In this article the focus is centered on patients who have a late relapse (>12 months). Carboplatin-based regimens are the backbone of treatment for this group, producing clinical benefit with higher rates for progression-free and overall survival. However, not all patients can continue with platinum owing to loss of activity or toxicity (hypersensitivity, neurotoxicity and ototoxicity). In particular, hypersensitivity reactions to carboplatin are a concern and have been reported in approximately 15-20% of women receiving the drug. When expectations for a positive outcome with carboplatin are good, desensitization protocols may be useful so as to continue treatment. If platinum-based regimens are not possible then alternative forms of treatment are required; additional research efforts are being directed towards the development of nonplatinum-based therapies. Promising results have been obtained with the combination of trabectedin plus pegylated liposomal doxorubicin, providing encouragement that it will be a viable option for patients with recurrent ovarian cancer who cannot be treated with a platinum-based chemotherapeutic option.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Platinum, gauze, 100 mesh, 99.9% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.025 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum black, black, powder, ≤20 μm, ≥99.95% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 0.25 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.127 mm, 99.99% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.1 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 0.076 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Platinum, shot, ≤3 mm, ≥99.9% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 0.127 mm, 99.9% trace metals basis
Sigma-Aldrich
Platinum black, fuel cell grade, ≥99.9% trace metals basis
Sigma-Aldrich
Platinum, foil, thickness 0.25 mm, 99.99% trace metals basis
Sigma-Aldrich
Platinum, wire, diam. 2.0 mm, 99.9% trace metals basis
Platinum, wire reel, 0.05m, diameter 0.20mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, tube, 500mm, outside diameter 1.2mm, inside diameter 1.0mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, tube, 50mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%
Platinum, tube, 50mm, outside diameter 3.0mm, inside diameter 2.8mm, wall thickness 0.1mm, as drawn, 99.95%
Platinum, foil, 0.1m coil, thickness 0.029mm, coil width .34mm, annealed, 99.99%
Platinum, foil, 10mm disks, thickness 0.025mm, as rolled, 99.99+%
Platinum, wire reel, 0.05m, diameter 0.25mm, as drawn, 99.998%
Platinum, foil, 8mm disks, thickness 0.0075mm, as rolled, 99.95%
Platinum, foil, 4mm disks, thickness 0.025mm, as rolled, 99.95%
Platinum, foil, 0.5m coil, thickness 0.045mm, coil width .75mm, as rolled, 99.95%
Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.95%
Platinum, foil, 0.2m coil, thickness 0.025mm, coil width 1.6mm, as rolled, 99.95%
Platinum, wire reel, 0.1m, diameter 0.006mm, wollaston, 99.9%
Platinum, foil, 6mm disks, thickness 0.004mm, as rolled, 99.95%
Platinum, foil, 15mm disks, thickness 0.025mm, as rolled, 99.99+%
Platinum, wire reel, 0.1m, diameter 0.125mm, annealed, may be used as one component of a thermocouple, 99.99%
Platinum, foil, 0.5m coil, thickness 0.025mm, coil width .85mm, as rolled, 99.95%
Platinum, foil, 4mm disks, thickness 0.0075mm, as rolled, 99.95%