SML1335

Pidotimod

≥98% (HPLC)

• Synonym(s): (4R)-3-(5-Oxo-L-prolyl)-1,3-thiazolidine-4-carboxylic acid, (R)-3-((S)-5-Oxopyrrolidine-2-carbonyl)thiazolidine-4-carboxylic acid, (R)-3-[(S)-(5-Oxo-2-pyrrolidinyl) carbonyl]-thiazolidine-4-carboxylic acid, 3-L-Pyroglutamyl-L-thiaziolidine-4carboxylic acid, PGT/1A
• Empirical Formula (Hill Notation): C₉H₁₂N₂O₄S
• CAS Number: 121808-62-6
• Molecular Weight: 244.27
• MDL number: MFCD00867583
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825793
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -135 to -155°, c = 1 in 6 M HCl
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: OC([C@@H]1CSCN1C([C@H]2NC(CC2)=O)=O)=O
• InChI: 1S/C9H12N2O4S/c12-7-2-1-5(10-7)8(13)11-4-16-3-6(11)9(14)15/h5-6H,1-4H2,(H,10,12)(H,14,15)/t5-,6-/m0/s1
• InChI key: UUTKICFRNVKFRG-WDSKDSINSA-N

Description

Biochem/physiol Actions

Pidotimod is a dipeptide immunostimulant with biological activity on both the adaptive and the innate immune responses. Pidotimod has been reported to modulate airway epithelial cells functions involved in host-virus interaction possibly through NF-kB activation, promote functional maturation of dendritic cells, and facilitate M2 macrophage polarization and function. Pidotimod has been investigated for use to increase response to recurrent respiratory infections primarily in children.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable