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  • Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling.

Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling.

Scientific reports (2015-05-12)
Xu Zhou, Ying Qi
ABSTRACT

Cancer neovascularization plays an essential role in the metastasis of larynx carcinoma (LC). However, the underlying molecular mechanisms are not completely understood. Recently, we reported that placental growth factor (PLGF) regulates expression of matrix metalloproteinase 3 (MMP3) through ERK/MAPK signaling pathway in LC. Here, we show that MMP9 upregulated in LC, and appeared to be mainly produced by M2 macrophages (tumor-associated macrophages (TAM)). In a transwell co-culture system, PLGF secreted by LC cells triggered macrophage polarization to a TAM subtype that releases MMP9. Moreover, MMP9 was found to be activated in the PLGF-polarized TAM via transforming growth factor β (TGFβ) receptor signaling activation. Furthermore, PLGF in LC cells induced macrophage polarization in vivo, and significantly promoted the growth of LC. Thus, together with our previous work, our study highlights a pivotal role of cross-talk between TAM and LC in regulating the metastasis of LC.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Placenta Growth Factor human, PlGF, recombinant, expressed in E. coli, powder, suitable for cell culture
Sigma-Aldrich
MISSION® esiRNA, targeting mouse Mki67