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Merck

Capecitabine-induced chest pain relieved by diltiazem.

The American journal of cardiology (2012-09-04)
Andrew P Ambrosy, Pamela L Kunz, George A Fisher, Ronald M Witteles
ABSTRACT

Five patients with primary colorectal adenocarcinoma or anal squamous cell carcinoma were started on a 2-weeks-on, 1-week-off capecitabine dosing regimen in addition to other chemotherapeutic agents and/or radiation. Within the first few doses, patients experienced chest pain and/or dyspnea at rest or with exertion. Acute electrocardiographic findings suggestive of ischemia were found in some cases at initial presentation, and 1 patient had troponin elevation consistent with an acute ST-segment elevation myocardial infarction. Subsequent ischemia evaluations were not suggestive of clinically significant coronary artery disease. All patients experienced immediate and sustained relief from chest pain after discontinuation of capecitabine and were able to successfully tolerate retreatment using a novel management strategy based on secondary prophylaxis with diltiazem. In conclusion, guidelines for the evaluation of and therapy for capecitabine-induced chest pain are proposed.

MATERIALS
Product Number
Brand
Product Description

Supelco
Diltiazem hydrochloride solution, 1.0 mg/mL in acetonitrile (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Diltiazem hydrochloride, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
(+)-cis-Diltiazem hydrochloride, ≥99% (HPLC)
Diltiazem for system suitability, European Pharmacopoeia (EP) Reference Standard