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  • Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents.

Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents.

Bioorganic & medicinal chemistry (2006-05-03)
Bhawani Singh Rathore, M Kumar
ABSTRACT

7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/beta-ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
α,α,α-Trifluorotoluene, anhydrous, ≥99%
Sigma-Aldrich
α,α,α-Trifluorotoluene, ≥99%
Sigma-Aldrich
α,α,α-Trifluorotoluene solution, NMR reference standard, 0.05% in benzene-d6 (99.6 atom % D), NMR tube size 3 mm × 8 in.
Sigma-Aldrich
α,α,α-Trifluorotoluene solution, NMR reference standard, 0.05% in benzene-d6 (99.6 atom % D)
Sigma-Aldrich
α,α,α-Trifluorotoluene solution, NMR reference standard, 0.05% in benzene-d6 (99.6 atom % D), NMR tube size 10 mm × 8 in.