PHR1216

Dibutyl sebacate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Decanedioic acid dibutyl ester, Sebacic acid dibutyl ester
• Linear Formula: [-(CH₂)₄CO₂(CH₂)₃CH₃]₂
• CAS Number: 109-43-3
• Molecular Weight: 314.46
• Beilstein: 1798308
• EC Number: 203-672-5
• MDL number: MFCD00027218
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823223
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1187091
• API family: dibutyl sebacate
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.441 (lit.)
• bp: 178-179 °C/3 mmHg (lit.)
• density: 0.936 g/mL at 25 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: CCCCOC(=O)CCCCCCCCC(=O)OCCCC
• InChI: 1S/C18H34O4/c1-3-5-15-21-17(19)13-11-9-7-8-10-12-14-18(20)22-16-6-4-2/h3-16H2,1-2H3
• InChI key: PYGXAGIECVVIOZ-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dibutyl sebacate is a commonly used plasticizer, which can be synthesized by the reaction of butyl alcohol and sebacyl chloride or by the distillation of sebacic acid with butyl alcohol in the presence of concentrated hydrochloric acid in benzene solution.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9029 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

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Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 366.8 °F - open cup
• Flash Point(C): 186 °C - open cup