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E-006

Supelco

EDDP perchlorate

ampule of 10 mg, certified reference material, Cerilliant®

Synonym(s):

EDDP perchlorate, 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine perchlorate

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About This Item

Empirical Formula (Hill Notation):
C20H23N · HClO4
CAS Number:
Molecular Weight:
377.86
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

form

solid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 10 mg

manufacturer/tradename

Cerilliant®

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

neat

storage temp.

−20°C

General description

A Certified Reference Material of the major urinary metabolite of methadone. Methadone, sold under various trade names such as Symoron, Amidone or Methadose®, is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. Suitable uses for this reference standard include as starting material in preparation of calibrators and controls for LC/MS or GC/MS methods in methadone testing for applications in clinical toxicology or forensic analysis.

Application


  • DNA precipitation: This compound is vital for DNA precipitation protocols where it facilitates the aggregation of DNA fragments by reducing their solubility in water. This application is essential for genetic engineering and molecular biology experiments (Park et al., 2023).

  • Cell culture: In cell culture, ammonium sulfate is used to control the osmotic pressure of culture media, which is crucial for maintaining the health and viability of cultured cells, thus supporting tissue engineering and cellular research (Qin et al., 2024).



Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Methadose is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Pricing

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Matthias Gosselin et al.
Forensic science international, 209(1-3), 154-159 (2011-02-16)
This paper describes a sensitive UPLC-MS/MS method for quantification of methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in single empty puparial case of Lucilia sericata. Larvae were reared on substrates spiked with different concentrations of methadone (0-4 μg/g). Methadone was quantified in puparia
Ana de Castro et al.
Clinical chemistry, 57(3), 449-458 (2011-01-20)
Few investigations have used placenta as an alternative matrix to detect in utero drug exposure, despite its availability at the time of birth and the large amount of sample. Methadone-maintained opioid-dependent pregnant women provide a unique opportunity to examine the
Ana de Castro et al.
Therapeutic drug monitoring, 33(4), 443-452 (2011-07-12)
The purpose was to explore methadone and 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) umbilical cord disposition, correlate with maternal methadone dose and neonatal outcomes, and evaluate the window of drug detection in umbilical cord of in utero illicit drug exposure. Subjects comprised 19 opioid-dependent
Edijs Leimanis et al.
Journal of analytical toxicology, 36(4), 239-249 (2012-04-19)
Methadone is used to treat moderate to severe pain in patients not responsive to non-narcotic analgesics and for maintenance treatment of opioid addiction. Methadone is primarily metabolized by N-demethylation to an inactive metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidene (EDDP) by CYP3A4 and CYP2B6. Establishing
M Rosa Boleda et al.
Chemosphere, 84(11), 1601-1607 (2011-06-15)
A total of seventy samples of drinking water were tested for non-controlled and illicit drugs. Of these, 43 were from Spanish cities, 15 from seven other European countries, three from Japan and nine from seven different Latin American countries. The

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