776874

K-Oxyma

97%

• Synonym(s): 2-Cyano-2-(hydroxyimino)acetic acid ethyl ester, potassium salt, Ethyl (hydroxyimino)cyanoacetate potassium salt
• Empirical Formula (Hill Notation): C₅H₅KN₂O₃
• CAS Number: 158014-03-0
• Molecular Weight: 180.20
• MDL number: MFCD26960809
• UNSPSC Code: 12352111
• PubChem Substance ID: 329767868
• NACRES: NA.22

Properties

• Assay: 97%
• form: powder
• reaction suitability: reaction type: Addition Reactions
• mp: 141-147
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: CCOC(/C(C#N)=N/[O-])=O.[K+]
• InChI: 1S/C5H6N2O3.K/c1-2-10-5(8)4(3-6)7-9;/h9H,2H2,1H3;/q;+1/p-1/b7-4+;
• InChI key: ZFBMUWGNRJITLS-KQGICBIGSA-M

Description

Application

• Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt
• Outperforms HOAt in sterically demanding peptide bond formations
• Compatible with carbodiimide-mediated; solution and solid phase peptide coupling;
• Less epimerization than HOBt in fragment condensation reactions
• K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character
• K-salt has a higher melting point than OxymaPure

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable