Pular para o conteúdo
MilliporeSigma

Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.

Brain research (2008-06-21)
Ahmet H Kaya, Rinske Vlamings, Sonny Tan, Lee Wei Lim, Peter J Magill, Harry W M Steinbusch, Veerle Visser-Vandewalle, Trevor Sharp, Yasin Temel
RESUMO

Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

MATERIAIS
Número do produto
Marca
Descrição do produto

Sigma-Aldrich
Citocromo c, ≥95% (SDS-PAGE)
SKU
Tamanho da embalagem
Disponibilidade
Preço
Quantidade
Sigma-Aldrich
Catalase from bovine liver, lyophilized powder, 2,000-5,000 units/mg protein
SKU
Tamanho da embalagem
Disponibilidade
Preço
Quantidade