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Merck

Solid state grinding as a tool to aid enantiomeric resolution by cocrystallisation.

Chemical communications (Cambridge, England) (2012-10-18)
Mark D Eddleston, Mihails Arhangelskis, Tomislav Friščić, William Jones
PMID23073186
RESUMO

The formation of diastereomeric cocrystals of malic acid and tartaric acid was investigated by liquid-assisted grinding in the solid state. We demonstrate that racemic malic acid can be converted into two distinct diastereomeric cocrystal phases by grinding with a single enantiomer of tartaric acid.

MATERIAIS
Número do produto
Marca
Descrição do produto
251380
Sigma-Aldrich
L-(+)-Tartaric acid, ACS reagent, ≥99.5%
T206
Sigma-Aldrich
D-(−)-Tartaric acid, ReagentPlus®, 99%
T400
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DL-Tartaric acid, ReagentPlus®, 99%
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L-(+)-Tartaric acid, ≥99.7%, FCC, FG
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L-(+)-Tartaric acid, ≥99.5%
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L-(+)-Tartaric acid, puriss. p.a., reag. ISO, 99.5-101.0% (calc. to the dried substance)
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L-(+)-Tartaric acid, anhydrous, free-flowing, Redi-Dri™, ACS reagent, ≥99.5%
95320
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D-(−)-Tartaric acid, puriss., unnatural form, ≥99.0% (T)
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L-(+)-Tartaric acid, BioXtra
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L-(+)-Tartaric acid, puriss., meets analytical specification of Ph. Eur., NF, 99.7-100.5% (calc. to the dried substance), powder
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Supelco
L-(+)-Tartaric acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland