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USP

Cefotaxima

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

Cefotaxim

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About This Item

Fórmula empírica (Notação de Hill):
C16H16N5NaO7S2
Número CAS:
64485-93-4
Peso molecular:
477.45
Beilstein:
5711411
Número MDL:
MFCD00079073
Código UNSPSC:
41116107
ID de substância PubChem:
329749255
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

cefotaxime

fabricante/nome comercial

USP

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O

InChI

1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

chave InChI

AZZMGZXNTDTSME-JUZDKLSSSA-M

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação


  • Rapid evolutionary change in trait correlations of single proteins: This article explores the rapid evolutionary changes in protein traits, providing a fundamental understanding that can inform biochemical studies using tools like Cefotaxime sodium to influence protein interactions in bacterial cells, enhancing the effectiveness of antibacterial therapies (Dasmeh et al., 2024).

  • Moringa oleifera as a potential antimicrobial against pathogenic Clostridium perfringens isolates in farm animals: Research investigates the antimicrobial properties of Moringa oleifera, with implications for enhancing the efficacy of antibiotic treatments like Cefotaxime sodium in combating bacterial infections in veterinary applications (Ibrahim and Altammar, 2024).

  • In vitro antibacterial activity of antibiotics and plant essential oils against Escherichia coli MTCC443 supported through the molecular docking and pharmacokinetics study: This study examines the synergistic effects of Cefotaxime sodium with plant essential oils against E. coli, highlighting its potential in developing new antibacterial combinations that enhance drug efficacy and reduce resistance (Jain et al., 2024).

  • Efficacy and safety of antibiotics for treatment of leptospirosis: a systematic review and network meta-analysis: This comprehensive review assesses the effectiveness of Cefotaxime sodium among other antibiotics in treating leptospirosis, offering critical insights into its clinical utility and safety profile (Ji et al., 2024).

  • Changing Landscape of Antimicrobial Resistance in Neonatal Sepsis: An in silico Analyses of Multidrug Resistance in Klebsiella pneumoniae: The study discusses the rising challenge of antibiotic resistance, emphasizing the role of Cefotaxime sodium in treating complex cases of neonatal sepsis, thus underlining the need for continuous research into its mechanisms and resistance patterns (Vijayakumar et al., 2024).

Ações bioquímicas/fisiológicas

A cefotaxima inibe a síntese da parede celular bacteriana ligando-se às proteínas de ligação à penicilina (PBP), o que inibe a etapa final de transpeptidação da síntese de peptidoglicano nas paredes celulares bacterianas. Como resultado, a bactéria sofre lise devido às enzimas autolíticas da parede celular.

Outras notas

Antibiótico cefalosporina de terceira geração de amplo espectro.
Sales restrictions may apply.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H317,H334

Classificações de perigo

Resp. Sens. 1 - Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Hien Bao Dieu Thai et al.
The Analyst, 140(8), 2804-2809 (2015-02-28)
We described a dual turn-on probe sensitive to both acidity and basicity, which could be designed by connecting a fluorophore to a quencher via metal-ligand interaction. Atto488-labeled nitrilotriacetic acid and polyhistidine peptide were used as the fluorophore and the quencher
R N Jones
Diagnostic microbiology and infectious disease, 13(4), 317-327 (1990-07-01)
Cefotaxime is a parenteral broad-spectrum cephalosporin, used extensively worldwide for chemotherapy of serious infections. Since its release in 1979, cefotaxime has also been studied to minimize surgery-related infections and, more than any other new compound, has been used in a
Siiri Kõljalg et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(5), 452-458 (2013-09-17)
The aim of our study was to characterize the phylogenetic groups of Escherichia coli, antibiotic resistance, and containment of class 1 integrons in the first attack of pyelonephritis and in subsequent recurrences in young children. Altogether, 89 urine E. coli
Alje P van Dam et al.
Sexually transmitted infections, 90(7), 513-514 (2014-08-13)
We describe the first case of treatment failure of gonorrhoea with a third generation cephalosporin, cefotaxime 1g intramuscularly, in the Netherlands. The case was from a high-frequency transmitting population (men having sex with men) and was caused by the internationally
Fu Peng et al.
Chinese medical journal, 127(23), 4001-4005 (2014-11-29)
Our pervious antibacterial studies on several traditional Chinese medicines have found that Patchouli oil from Pogostemon cablin had significant antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), which has spread worldwide and infected innumerable people. In order to find the more
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