SAB4300523

Anti-EIF2S1 (Ab-51) antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Anti-EIF-2 antibody produced in rabbit, Anti-EIF-2A antibody produced in rabbit, Anti-EIF-2alpha antibody produced in rabbit, Anti-EIF2 antibody produced in rabbit, Anti-eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa antibody produced in rabbit
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: ~38 kDa
• reatividade de espécies: human, mouse, rat
• concentração: 1 mg/mL
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotipo: IgG
• sequência de imunogênio: (E-L-S-R-R)
• nº de adesão NCBI: NP_004085.1
• nº de adesão UniProt: P05198
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... EIF2S1(1965)

Descrição

Descrição geral

The eukaryotic translation initiation factor 2 subunit α (EIF2S1) gene codes for a heterotrimeric GTPase which is localized to the cytoplasm. The EIF2S1 gene is mapped to human chromosome 14q23.3.

Imunogênio

Peptide sequence around aa. 49-53 (E-L-S-R-R), according to the protein EIF2S1.

Ações bioquímicas/fisiológicas

EIF2S1 (eukaryotic translation initiation factor 2 subunit α) serves as an important enzyme in protein elongation during translation. EIF2S1 catalyses the translocation of peptidyl-tRNA from A site to P site in the ribosome. Phosphorylation by EF2 kinase, inactivates EIF2S1 followed by inhibition of protein synthesis. Upregulation of EIF2S1 gene is observed in malignant tumors, such as gastrointestinal cancer, lung adenocarcinoma, ovary cancer, soft-tissue sarcomas and hepatocellular carcinoma. The GTP-bound eIF2S1 protein is regarded as the active form and recruits initiator methionyl tRNA to 40S ribosomal subunit, one of the key step in translation initiation.

Características e benefícios

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Descrição-alvo

Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable