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S8326

Sigma-Aldrich

SKI 5C

≥98% (HPLC)

Sinônimo(s):

2,2-Dimethyl-4S-(1-oxo-2-hexadecyn-1-yl)-1,1-dimethylethyl ester-3-oxazolidinecarboxylic acid, SPHK1 Inhibitor 5C

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About This Item

Fórmula empírica (Notação de Hill):
C26H45NO4
Número CAS:
120005-55-2
Peso molecular:
435.64
Número MDL:
MFCD18428021
Código UNSPSC:
12352202
ID de substância PubChem:
329824601

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

oil

cor

colorless to light brown

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CCCCCCCCCCCCCC#CC(=O)[C@@H]1COC(C)(C)N1C(=O)OC(C)(C)C

InChI

1S/C26H45NO4/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(28)22-21-30-26(5,6)27(22)24(29)31-25(2,3)4/h22H,7-18,21H2,1-6H3/t22-/m0/s1

chave InChI

YGBSGZPIDCXNEH-QFIPXVFZSA-N

Aplicação

SKI 5C was used to inhibit Sphingosine kinase 1 in SK-Hep1, HEK-293T cells.1

Ações bioquímicas/fisiológicas

SKI 5C is a selective Sphingosine Kinase 1 (SPHK1) inhibitor.

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Youmna Atieh et al.
Current biology : CB, 31(6), 1129-1140 (2021-01-06)
Extrusion is a mechanism used to eliminate unfit, excess, or dying cells from epithelial tissues. The initial events guiding which cells will be selectively extruded from the epithelium are not well understood. Here, we induced damage in a subset of
Meiyan Bao et al.
Liver international : official journal of the International Association for the Study of the Liver, 32(2), 331-338 (2011-11-22)
Sphingosine kinase 1 (SphK1), which phosphorylates sphingosine to sphingosine-1-phosphate (S1P), is overexpressed in various types of cancers, and may act as an oncogene in tumorigenesis. However, little is known about the precise role of the SphK1/S1P pathway in human liver
Sebastian Wurster et al.
Cell reports, 34(12), 108896-108896 (2021-03-25)
Severe and often fatal opportunistic fungal infections arise frequently following mucosal damage caused by trauma or cytotoxic chemotherapy. Interaction of fungal pathogens with epithelial cells that comprise mucosae is a key early event associated with invasion, and, therefore, enhancing epithelial

Artigos

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

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