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S6508

Sigma-Aldrich

Sodium orthovanadate

≥90% (titration)

Sinônimo(s):

Trisodium vanadate

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About This Item

Fórmula linear:
Na3VO4
Número CAS:
13721-39-6
Peso molecular:
183.91
Número CE:
237-287-9
Número MDL:
MFCD00003511
Código UNSPSC:
12352200
ID de substância PubChem:
24899708
NACRES:
NA.77

fonte biológica

synthetic (organic)

Ensaio

≥90% (titration)

forma

crystalline powder

adequação da reação

reagent type: catalyst
core: vanadium

cor

white to off-white

pf

850-866 °C (lit.)

solubilidade

H2O: soluble

cadeia de caracteres SMILES

[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O

InChI

1S/3Na.4O.V/q3*+1;;3*-1;

chave InChI

IHIXIJGXTJIKRB-UHFFFAOYSA-N

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Aplicação

Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.26 It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.27

Ações bioquímicas/fisiológicas

Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25
Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

P7626

Fluoreto de fenilmetanosulfonil

Sodium pyrophosphate dibasic practical grade

Sigma-Aldrich

P8135

Sodium pyrophosphate dibasic

Leupeptina microbial, ≥90% (HPLC)

Sigma-Aldrich

L2884

Leupeptina

Christopher N J Young et al.
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P2RX7 is an ATP-gated ion channel, which can also exhibit an open state with a considerably wider permeation. However, the functional significance of the movement of molecules through the large pore (LP) and the intracellular signaling events involved are not
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Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na(+)/K(+))-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis procera, which is
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Transcriptional repressor complexes containing p130 and E2F4 regulate the expression of genes involved in DNA replication. During the G1 phase of the cell cycle, sequential phosphorylation of p130 by cyclin-dependent kinases (Cdks) disrupts these complexes allowing gene expression. The Cdk
Roser Buscà et al.
BMC evolutionary biology, 15, 179-179 (2015-09-04)
The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due
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Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic
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