N1271

Narasin from Streptomyces auriofaciens

≥98% (HPLC)

• Sinônimo(s): 4-methylsalinomycin, Monteban, narasin A
• Fórmula empírica (Notação de Hill): C₄₃H₇₂O₁₁
• Número CAS: 55134-13-9
• Peso molecular: 765.03
• Número MDL: MFCD00133653
• Código UNSPSC: 51102829
• ID de substância PubChem: 24897476
• NACRES: NA.85

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥98% (HPLC)
• forma: powder
• solubilidade: methanol: soluble 20 mg/mL
• espectro de atividade do antibiótico: Gram-positive bacteria; fungi; viruses
• Modo de ação: cell membrane | interferes
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCC(C1OC(C(C)CC1C)C(C)C(O)C(C)C(=O)C(CC)C2OC3(OC4(CCC(C)(O4)C5CCC(O)(CC)C(C)O5)C(O)C=C3)C(C)CC2C)C(O)=O
• InChI: 1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)
• chave InChI: VHKXXVVRRDYCIK-UHFFFAOYSA-N

Descrição

Aplicação

Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. It inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.

Ações bioquímicas/fisiológicas

Narasin administration in swine results in improved nitrogen digestibility, which decreases fecal nitrogen and increases the relative concentrations of propionic acid in the large intestine. Polyether ionophores, such as Narasin, have a hydrophilic interior and a hydrophobic exterior. The lipophilic ionophore attaches to the lipid rich cell membranes of Gram-positive bacteria. Ionophores bind Na⁺, K⁺, and H⁺ and facilitate their transfer across the bacterial cell membrane, resulting in an increase in H⁺ concentration on the inside of the Gram-positive cell. Therefore, the H⁺ ATPase pump is activated to transport out excess H⁺. The cell is depleted of its energy resources and reduces fermentative functions and cell division .

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 2 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges