MAK218

Tace Inhibitor Screening Assay Kit

Sufficient for 100 Fluorometric tests

• Sinônimo(s): ADAM Metallopeptidase Domain 17, ADAM17 Inhibitor Screening Assay Kit, Tumor Necrosis Factor-α-converting enzyme Inhibitor Screening Kit
• Número CE: 200-664-3
• Código UNSPSC: 12352200
• NACRES: NA.84

Propriedades

• método de detecção: fluorometric
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... ADAM17(6868) ; mouse ... ADAM17(11491) ; rat ... ADAM17(57027)

Descrição

Descrição geral

Tumor necrosis factor-a converting enzyme (TACE; ADAM17) is a member of the ADAM (A Disintegrin And Metalloprotease) protein family implicated in cell-cell and cell-matrix interactions. TACE activates Notch signaling in the epidermal cells and has a critical function in the maintenance of barrier immunity. It is also involved in neurogenesis and muscle development.

Aplicação

Tace Inhibitor Screening Assay Kit has been used in TACE (TNFa converting enzyme) activity assays.

Características e benefícios

Compatible with high-throughput handling systems.

Adequação

Suitable for the screening of inhibitors of TACE.

Princípio

The TACE Inhibitor Screening Assay Kit is a rapid, simple and sensitive assay that is suitable for high throughput screening of TACE inhibitors. TACE hydrolyzes a FRET-tagged substrate to release a fluorescent product (λ_ex = 318/ λ_em = 449 nm), proportional to the enzymatic activity present.

Somente componentes do kit

• TACE Assay Buffer
• TACE Substrate
• TACE Enzyme
• Inhibitor Control, 0.1 mM GM6001

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H334
• Declarações de precaução: P261 - P284 - P501
• Classificações de perigo: Resp. Sens. 1
• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3