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B8061

Sigma-Aldrich

N-Butyl-N-(4-hydroxybutyl)nitrosamine

ISOPAC®, ≥90% (GC)

Sinônimo(s):

BBN, N-Butyl-N-butan-4-ol-nitrosamine, N-Butyl-N-nitroso-4-aminobutanol, OH-BBN

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About This Item

Fórmula empírica (Notação de Hill):
C8H18N2O2
Número CAS:
3817-11-6
Peso molecular:
174.24
Código UNSPSC:
12352116
NACRES:
NA.25

Ensaio

≥90% (GC)

forma

liquid

temperatura de armazenamento

2-8°C

InChI

1S/C8H18N2O2/c1-2-3-6-10(9-12)7-4-5-8-11/h11H,2-8H2,1H3

chave InChI

DIKPQFXYECAYPC-UHFFFAOYSA-N

Aplicação

N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN), a carcinogen, is used to induce histiologically relevant aggressive urinary bladder cancer in animal models.

Ações bioquímicas/fisiológicas

Carcinogen used to induce urinary bladder cancer in animal models. The result of exposure is histologically comparable to human urinary bladder tumorigenesis. Used in chemopreventative studies.

Embalagem

Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.

Atenção

Injecting any compatible solvent permits preparation of any desired strength solution without exposure.

Reconstituição

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Informações legais

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Danger

Frases de perigo

H302,H350

Classificações de perigo

Acute Tox. 4 Oral - Carc. 1B

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

296.6 °F

Ponto de fulgor (°C)

147 °C

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Tamoxifeno ≥99%

Sigma-Aldrich

T5648

Tamoxifeno

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Green tea polyphenol (GTP) suppresses malignancy in bladder cancer cell lines. However, the detail of its anti-carcinogenic effect in vivo is not fully understood. This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given
João C Fernandes et al.
Marine drugs, 10(12), 2661-2675 (2013-01-25)
Urinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange
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We previously reported that the expression of CXC chemokine receptor-4 (CXCR4) was upregulated in invasive bladder cancers and that the small peptide T140 was a highly sensitive antagonist for CXCR4. In this study, we identified that CXCR4 expression was induced
Xiao-Li Xie et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 3934-3940 (2012-08-15)
In the present study, effects of L-leucine and L-isoleucine on rat bladder carcinogenesis were investigated using AIN-93G and MF basal diet. In Experiment 1, N-butyl-N-(4-hydroxybutyl)-nitrosamine was used as an initiator of bladder carcinogenesis. In the AIN-93G diet groups, a significantly
Zhiming He et al.
Mutation research, 742(1-2), 92-95 (2011-12-14)
Bladder cancer is one of the few cancers that have been linked to carcinogens in the environment and tobacco smoke. Of the carcinogens tested in mouse chemical carcinogenesis models, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is one that reproducibly causes high-grade, invasive cancers in
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