AV46122

Anti-HIST1H1C antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Anti-H1.2, Anti-H1F2, Anti-Histone cluster 1, H1c, Anti-MGC3992
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: 21 kDa
• reatividade de espécies: human
• concentração: 0.5 mg - 1 mg/mL
• técnica(s): ChIP: suitable; western blot: suitable
• nº de adesão NCBI: NP_005310
• nº de adesão UniProt: P16403
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... HIST1H1C(3006)

Descrição

Descrição geral

Histone H1 proteins are linker histones that interacts with linker DNA between nucleosomes to compact chromatin into higher order structures. There are multiple histone one genes in the histone 1 cluster that produce histone 1 variants. Histone cluster 1, H1c (HIST1H1C) is the H1C variant of histone 1 that is differentially expressed by cells.

Especificidade

Anti-HIST1H1C polyclonal antibody reacts with human, mouse, rat, chicken, and pig H1c variants of histone 1 proteins.

Imunogênio

Synthetic peptide directed towards the middle region of human HIST1H1C

Aplicação

Anti-HIST1H1C polyclonal antibody is used to tag the H1c variant of histone 1 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the differential expression of histone 1, H1c versus other histone 1 proteins during cell differentiation.

Ações bioquímicas/fisiológicas

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Sequência

Synthetic peptide located within the following region: ASGSFKLNKKAASGEAKPKVKKAGGTKPKKPVGAAKKPKKAAGGATPKKS

forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable