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Merck
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Key Documents

73361

Sigma-Aldrich

Bis[2-(N-succinimidyl-oxycarbonyloxy)ethyl] sulfone

≥97.0% (CHN)

Sinônimo(s):

BSOCOES

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About This Item

Fórmula empírica (Notação de Hill):
C14H16N2O12S
Número CAS:
Peso molecular:
436.35
Beilstein:
1521053
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:

Ensaio

≥97.0% (CHN)

adequação da reação

reagent type: cross-linking reagent

pf

169-173 °C

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O=C1CCC(=O)N1OC(=O)OCCS(=O)(=O)CCOC(=O)ON2C(=O)CCC2=O

InChI

1S/C14H16N2O12S/c17-9-1-2-10(18)15(9)27-13(21)25-5-7-29(23,24)8-6-26-14(22)28-16-11(19)3-4-12(16)20/h1-8H2

chave InChI

XUDGDVPXDYGCTG-UHFFFAOYSA-N

Outras notas

Homobifunctional crosslinking reagent for proteins; cross-linking reagents used as molecular rulers

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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E Antonian et al.
European journal of biochemistry, 145(3), 511-517 (1984-12-17)
Calf brain plain synaptic vesicle proteins have been cross-linked with bis[2-(succinimidooxycarbonyloxy)ethyl] sulfone, a homobifunctional, cleavable reagent, as well as with N-hydroxysuccinimidyl 4-azidobenzoate, a photosensitive, heterobifunctional reagent. These results demonstrate the generality of a recent report that synaptic vesicle proteins can
R A Smith et al.
The Journal of biological chemistry, 261(21), 9850-9853 (1986-07-25)
The quaternary structural relationships between subunits of the follitropin (FSH) receptor were determined through the use of the reversible, homobifunctional, chemical cross-linking reagent bis[2-(succinimidooxycarbonyloxy)ethyl]sulfone (BSOCOES) after formation of covalent 125I-azidobenzoyl-FSH-receptor subunit complexes by photoaffinity labeling. This experimental approach resulted in
J Shin et al.
The Journal of biological chemistry, 260(23), 12822-12827 (1985-10-15)
Both of the alpha and beta subunits of intact human follitropin (FSH) were radioiodinated with 125I-sodium iodide and chloramine-T and could be resolved on sodium dodecyl sulfate-polyacrylamide gels. Radioiodinated FSH was affinity-cross-linked with a cleavable (nondisulfide) homobifunctional reagent to its
Z Bouizar et al.
European journal of biochemistry, 155(1), 141-147 (1986-02-17)
We have characterized the binding parameters of renal receptors (Scatchard analysis revealed the presence of two binding sites: site I, Ka1 = 1.29 X 10(9) M-1, number of binding sites = 9.9 X 10(6)/micrograms protein; site II, Ka2 = 0.93
P Gourlet et al.
Journal of receptor research, 11(5), 831-848 (1991-01-01)
Cross-linking of [125I]helodermin to human SUP-T1 lymphoblasts with bis[2-(succinimidooxycarbonyloxy)ethyl]sulfone (BSOCOES) revealed a 63 K binding protein. This cross-linking was inhibited by helodermin and VIP. In cells submitted for 3-4 days to 0.2 microgram/ml tunicamycin, the Mr of an increasing proportion

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