05130

L-Alanine

≥99.0% (NT)

• Sinônimo(s): (S)-2-Aminopropionic acid, L-α-Aminopropionic acid
• Fórmula empírica (Notação de Hill): C₃H₇NO₂
• Número CAS: 56-41-7
• Peso molecular: 89.09
• Beilstein: 1720248
• Número CE: 200-273-8
• Número MDL: MFCD00064410
• Código UNSPSC: 12352209
• eCl@ss: 32160406
• ID de substância PubChem: 329747640
• NACRES: NA.26

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥99.0% (NT)
• Formulário: powder or crystals
• atividade óptica: [α]20/D +14.0±1°, c = 5% in 5 M HCl
• Impurezas: ≤0.3% foreign amino acids
• resíduo de ignição: ≤0.1% (as SO₄)
• perda: ≤0.1% loss on drying, 110 °C
• cor: colorless to white
• pf: 314.5 °C
• solubilidade: H₂O: soluble 89.1 g/l at 20 degrees c; diethyl ether: insoluble; ethanol: soluble (cold 80%)
• traços de ânion: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• traços de cátion: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; NH₄⁺: ≤100 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• aplicação(ões): detection; peptide synthesis
• cadeia de caracteres SMILES: C[C@H](N)C(O)=O
• InChI: 1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
• chave InChI: QNAYBMKLOCPYGJ-REOHCLBHSA-N

Descrição

Aplicação

L-Alanine is used as a standard to determine absolute concentration of a protein within a mixture of other proteins measured with SI traceability.[1]

Ações bioquímicas/fisiológicas

Alanine is a nonessential amino acid that plays a key role in the glucose-alanine cycle between muscle tissue and the liver. In amino acid-degrading tissues such as muscle, amino groups are pooled as glutamate by transamination reactions. The amino group of glutamate is transferred to pyruvate via alanine aminotransferase, forming alanine and α-ketoglutarate. The alanine is passed into the blood and transported to the liver. This reaction is reversed in the liver where pyruvate can be used in gluconeogenesis to form glucose, which may return to other tissues through the circulatory system. Increased alanine levels correlate with higher blood pressure, energy intake, cholesterol levels, and body mass index.

L-alanine has the ability to promote the expression of ferritin and antioxidant stress proteins, heme oxygenase-1 (HO-1).[2]

Nota de preparo

L-Alanine completely dissolves in water at a concentration of 89.1 g/l at 20°C to yield solution. It is also soluble in 80% ethanol and insoluble in ether.

Outras notas

Preparation of 2-chloropropionic acid[3][4]; Reduction of derivatives to the aldehyde[5][6]

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)