MABS409
Anti-NFATc1 Antibody, clone 7A6
clone 7A6, from mouse
Sinônimo(s):
Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-Atc, NFATc
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
7A6, monoclonal
reatividade de espécies
human, mouse
técnica(s)
flow cytometry: suitable
immunofluorescence: suitable
western blot: suitable
Isotipo
IgG1
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... NFATC1(4772)
Descrição geral
NFATc1, also known as Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, is a component of the nuclear factor of activated T cells DNA-binding transcription complex which consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. This protein plays a main role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription and functions as a major molecular target for the immunosuppressive drugs such as cyclosporine A. NFATc1 is expressed in most human primary lymphocytes and mature human T- and B-cell neoplasms.
Imunogênio
Recombinant protein of human NFATc1 amino acids 197-304
Aplicação
Detect NFAT using this mouse monoclonal antibody, Anti-NFATc1 Antibody, clone 7A6 validated for use in western blotting, Flow Cytometry & Immunofluorescence.
Flow Cytometry Analysis: A representative lot detected human NFATc1 in Flow Cytometry. (Brandt C, et al. 2010.)
Immunofluorescent Analysis: A representative lot detected human NFATc1 in Immunofluorescence. (Timmerman LA, et al. 1997.)
Immunofluorescent Analysis: A representative lot detected human NFATc1 in Immunofluorescence. (Timmerman LA, et al. 1997.)
Qualidade
Evaluated by Western Blotting in Jurkat, human Th1, and mouse Th1 cell extracts.
Western Blotting Analysis: 1 μg/mL of this antibody detected in Jurkat, human Th1, and mouse Th1 cell extracts.
Western Blotting Analysis: 1 μg/mL of this antibody detected in Jurkat, human Th1, and mouse Th1 cell extracts.
Descrição-alvo
~~95, ~110 and ~130 kDa observed
forma física
Format: Purified
Purified mouse monoclonal IgG1 antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide.
Armazenamento e estabilidade
The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Journal of hepatology, 74(3), 550-559 (2020-10-12)
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