FCMAB250A4

Milli-Mark^® Anti-Bcl-2 Antibody, Alexa Fluor^™488, clone AW604

clone AW604, Milli-Mark^®, from mouse

• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• conjugado: ALEXA FLUOR^™ 488
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: AW604, monoclonal
• reatividade de espécies: human
• fabricante/nome comercial: Milli-Mark^®
• técnica(s): flow cytometry: suitable
• Isotipo: IgG2a
• nº de adesão NCBI: NP_000624
• nº de adesão UniProt: P10415
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... BCL2(596)

Descrição

Descrição geral

Bcl-2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 also regulates cell death by controlling the mitochondrial membrane permeability and appears to function in a feedback loop system with caspases. It appears to Inhibit caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Further understanding in how Bcl-2 functions and interacts with other proteins to promote or inhibit apoptosis may lead to new treatments for cancer, neurological disorders and autoimmune diseases.

Especificidade

Antibody recognizes Bcl-2.

Imunogênio

KLH-conjugated, synthetic peptide corresponding to human Bcl-2

Aplicação

Research Category
Apoptosis & Cancer

Research Sub Category
BCL2 & Inhibition

This Milli-Mark Bcl-2 antibody is validated for use in Flow for the detection of the Milli-Mark Bcl-2 protein.

Qualidade

Evaulated by flow cytometery using Jurkat cells.

Descrição-alvo

26 kDa Calculated

forma física

Protein G Purified

Purified mouse monoclonal IgG2a conjugated to Alexa Fluor^™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Armazenamento e estabilidade

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Nota de análise

Control
Jurkat Cells

Informações legais

ALEXA FLUOR is a trademark of Life Technologies

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Alexa Fluor^™ is a registered trademark of Molecular Probes, Inc.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable