AB6002
Anti-MMP-1 Antibody, hinge region
from rabbit, purified by affinity chromatography
Sinônimo(s):
Fibroblast collagenase, Matrix metalloproteinase-1, matrix metallopeptidase 1, interstitial collagenase, matrix metalloprotease 1
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
purificado por
affinity chromatography
reatividade de espécies
human
técnica(s)
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... MMP1(4312)
Descrição geral
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn2+ binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). MMP1, also known as interstitial collagenase, is the only enzyme able to initiate the breakdown of the interstitial collagens, types I, II, and III.
Especificidade
Additional sequence homology is noted with mouse (81%) and rat (75%).
The antibody recognizes an internal domain of human MMP-1 containing the hinge region. It does not cross react with MMP-2, MMP-9, or MMP-13.
Imunogênio
KLH-conjugated synthetic peptide corresponding to the hinge region of human MMP-1.
Aplicação
Anti-MMP-1 Antibody, hinge region is an antibody against MMP-1 for use in WB.
Qualidade
Evaluated on a representative lot by Western blot on A431 cell lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected MMP-1 on 10 µg of A431 cell lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected MMP-1 on 10 µg of A431 cell lysate.
Descrição-alvo
54 kDa In Western Blot, bands around 53 kDa and 51 kDa (proenzyme) are observed in reduced proteins.
Ligação
Replaces: 04-1122
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Katherine Bleavins et al.
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Seniz Inanc et al.
BioTechniques, 63(4), 174-180 (2017-10-20)
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