537011
Prolyl Endopeptidase Inhibitor II
The Prolyl Endopeptidase Inhibitor II, also referenced under CAS 108708-25-4, controls the biological activity of Prolyl Endopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Sinônimo(s):
Prolyl Endopeptidase Inhibitor II, Z-PP-CHO
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About This Item
Fórmula empírica (Notação de Hill):
C18H22N2O4
Número CAS:
Peso molecular:
330.38
Código UNSPSC:
12352200
Produtos recomendados
Nível de qualidade
Ensaio
≥97% (HPLC)
forma
oil
fabricante/nome comercial
Calbiochem®
condição de armazenamento
OK to freeze
protect from light
cor
colorless to off-white
solubilidade
DMSO: 10 mg/mL
DMF: soluble
ethyl acetate: soluble
Condições de expedição
ambient
temperatura de armazenamento
−20°C
Descrição geral
A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively). Reported to form a hemiacetal with the active-site serine.
A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow, and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain, respectively). Reported to form a hemiacetal with the active site serine of the enzyme.
Ações bioquímicas/fisiológicas
Cell permeable: yes
Primary Target
Mouse brain prolylendooeotidase
Mouse brain prolylendooeotidase
Product does not compete with ATP.
Reversible: no
Target Ki: 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively
Embalagem
Packaged under inert gas
Advertência
Toxicity: Standard Handling (A)
Sequência
Z-Pro-Pro-CHO
Reconstituição
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Outras notas
Fülöp, V., et al. 1998. Cell94, 161.
Kahyaoglu, A., et al. 1997. Biochem. J.322, 839.
Bakker, A.V., et al. 1990. Biochem. J.271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem.41, 69.
Kahyaoglu, A., et al. 1997. Biochem. J.322, 839.
Bakker, A.V., et al. 1990. Biochem. J.271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem.41, 69.
Informações legais
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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