422682

K _ir1.1 Inhibitor, VU591

The K_ir1.1 Inhibitor, VU591 controls the biological activity of K_ir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Sinônimo(s): K _ir1.1 Inhibitor, VU591
• Fórmula empírica (Notação de Hill): C₁₆H₁₂N₆O₅
• Número CAS: 1222810-74-3
• Peso molecular: 368.30
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: light gray
• solubilidade: DMSO: 100 mg/mL, clear, dark brown
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

A cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, K_ir1.1 (IC₅₀ = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over K_ir6.2. In addition, it exhibits a modest off-target effect on the GABA_A receptor (IC₅₀ = 6.2 µM) among a panel of cardiac and central nervous system ion channels and receptors.

The K_ir1.1 Inhibitor, VU591 controls the biological activity of K_ir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Regulatory Review (Z)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Bhave, G., et al. 2011. Mol Pharmacol.79, 42.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable