07-218
Anti-Notch1 Antibody, extracellular domain
Upstate®, from rabbit
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
fonte biológica
rabbit
Nível de qualidade
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
reatividade de espécies
rat, mouse
fabricante/nome comercial
Upstate®
técnica(s)
western blot: suitable
Isotipo
IgG
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
Informações sobre genes
human ... NOTCH1(4851)
Descrição geral
The Notch protein family is a group of highly conserved proteins important in the determination of cell fate and maintenance of progenitors in many developmental systems. This family of proteins function both as membrane cell receptors and as transcription factors. Activation of Notch by cell-cell interactions causes a transcription inhibitory effect that enables inhibition of differentiation in some cells but not in others. As a consequence, some cells adopt a particular fate while other progenitors remain uncommitted. The Notch protein is important in cell fate during myogenesis, neurogenesis, oogenesis, and wing and eye development in Drosophila. In mammals, four Notch genes were identified (Notch 1-4) that are expressed in a wide variety of cells and play a crucial role in differentiation and development.
Especificidade
Notch1
Imunogênio
N-terminal GST fusion protein corresponding to residues 381-853 of rat Notch1
Aplicação
Anti-Notch1 Antibody, extracellular domain is a high quality Rabbit Polyclonal Antibody for the detection of Notch1 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Used in mouse in the following publication: Gulino, R., et al, European Journal of Neuroscience, Vol. 31, pp. 1423–1434, 2010.
Qualidade
Routinely evaluated by immunoblot on RIPA lysates from L/N17 rat Notch1 transfected fibroblast cells
Descrição-alvo
260kDa
Ligação
Replaces: 04-1046
forma física
Format: Purified
Protein A chromatography
Protein A purified immunoglobulin presented in 0.1M Tris-Glycine, 0.15M NaCl, and 0.05% Sodium Azide, pH 7.4
Armazenamento e estabilidade
Stable for 1 year at 2-8°C from date of receipt.
Nota de análise
Control
L/N17 transfected Notch1 cell lysate
L/N17 transfected Notch1 cell lysate
Informações legais
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10-13 - German Storage Class 10 to 13
Certificados de análise (COA)
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Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis
Garces, C, et al
The Journal of Biological Chemistry, 272, 29729-29734 (1997)
C M Blaumueller et al.
Cell, 90(2), 281-291 (1997-07-25)
Previous models for signal transduction via the Notch pathway have depicted the full-length Notch receptor expressed at the cell surface. We present evidence demonstrating that the Notch receptor on the plasma membrane is cleaved. This cleavage is an evolutionarily conserved
NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
Oswald, F, et al
Molecular and cellular biology, 18, 2077-2088 (1998)
Notch signaling: direct or what?
Weinmaster, G
Current Opinion in Genetics & Development, 8, 436-442 (1998)
G Struhl et al.
Cell, 93(4), 649-660 (1998-05-30)
The Drosophila Notch (N) gene encodes a conserved single-pass transmembrane receptor that transduces extracellular signals controlling cell fate. Here, we present evidence that the intracellular domain of Notch gains access to the nucleus in response to ligand, possibly through a
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