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W333301

Sigma-Aldrich

3-Butylidenephthalide

mixture of cis and trans isomers, ≥96%, FG

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About This Item

Fórmula empírica (Notação de Hill):
C12H12O2
Número CAS:
551-08-6
Peso molecular:
188.22
Número FEMA:
3333
Número CE:
208-991-3
Conselho da Europa nº:
10083
Número MDL:
MFCD00047319
Código UNSPSC:
12164502
ID de substância PubChem:
24901649
Número de Flavis:
10.024
NACRES:
NA.21

fonte biológica

synthetic

grau

FG
Halal
Kosher

conformidade reg.

EU Regulation 1334/2008 & 872/2012
FDA 21 CFR 110

Ensaio

≥96%

índice de refração

n20/D 1.577 (lit.)

pb

139-142 °C/5 mmHg (lit.)

densidade

1.103 g/mL at 25 °C (lit.)

aplicação(ões)

flavors and fragrances

Documentação

see Safety & Documentation for available documents

alérgeno alimentar

no known allergens

Organoléptico

herbaceous

cadeia de caracteres SMILES

CCC\C=C1/OC(=O)c2ccccc12

InChI

1S/C12H12O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-8H,2-3H2,1H3/b11-8-

chave InChI

WMBOCUXXNSOQHM-FLIBITNWSA-N

Descrição geral

3-Butylidenephthalide is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort.

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palavra indicadora

Warning

Frases de perigo

H302,H411

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Chronic 2

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

235.4 °F - closed cup

Ponto de fulgor (°C)

113 °C - closed cup

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Chyou-wei Wei et al.
Acta pharmacologica Sinica, 30(9), 1297-1306 (2009-08-25)
To investigate the role of hTERT gene expression and AP-2alpha in n-butylidenephthalide (n-BP)-induced apoptosis in A549 lung cancer cells. Viability of A549 cells was measured by MTT assay. Protein expression was determined by Western blot. Telomerase activity was measured using
Sheng-Chun Chiu et al.
PloS one, 7(3), e33742-e33742 (2012-04-04)
N-butylidenephthalide (BP) exhibits antitumor effect in a variety of cancer cell lines. The objective of this study was to obtain additional insights into the mechanisms involved in BP induced cell death in human prostate cancer cells. Two human prostate cancer
Po-Cheng Lin et al.
Journal of neurochemistry, 106(3), 1017-1026 (2008-04-19)
The natural compound n-butylidenephthalide (BP), which is isolated from the chloroform extract of Angelica sinensis, has been investigated for its antitumoral effects on glioblastoma multiform (GBM) brain tumors both in vitro and in vivo. To determine the mechanism of BP-induced
Andreas Schinkovitz et al.
Journal of natural products, 71(9), 1604-1611 (2008-09-11)
Monomeric phthalides such as Z-ligustilide (1) and Z-butylidenephthalide (2) are major constituents of medicinal plants of the Apiaceae family. While 1 has been associated with a variety of observed biological effects, it is also known for its instability and rapid
Yung-Luen Yu et al.
Journal of agricultural and food chemistry, 58(3), 1630-1638 (2010-01-02)
Epigenetic alteration of DNA methylation plays an important role in the regulation of gene expression associated with chemosensitivity of human hepatocellular (HCC) carcinoma cells. With the aim of improving the chemotherapeutic efficacy for HCC, the effect of the naturally occurring
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