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Merck

KCNA3

potassium voltage-gated channel, shaker-related subfamily, member 3

Sinônimos:
HGK5, HLK3, HPCN3, HUKIII, KV1.3, MK3, PCN3
Espécies:
ID UniProtKB:
ID do gene:
  • Human(3738) Summary: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]
  • Mouse(16491) potassium voltage-gated channel, shaker-related subfamily, member 3
  • Rat(29731) potassium voltage-gated channel, shaker-related subfamily, member 3
  • cow(525507) potassium voltage-gated channel, shaker-related subfamily, member 3
  • domestic cat(101092201) potassium voltage-gated channel, shaker-related subfamily, member 3
  • dog(490110) potassium voltage-gated channel, shaker-related subfamily, member 3
  • chicken(404303) potassium voltage-gated channel, shaker-related subfamily, member 3
  • naked mole-rat(101719045) potassium voltage-gated channel, shaker-related subfamily, member 3
  • domestic guinea pig(100721847) potassium voltage-gated channel, shaker-related subfamily, member 3
  • sheep(101105466) potassium voltage-gated channel, shaker-related subfamily, member 3
  • Domestic Rabbit(100328945) potassium voltage-gated channel, shaker-related subfamily, member 3

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-Potassium Channel Kv1.3 Antibody, extracellular domain, Chemicon®, from rabbit,
Reatividade de espécies
human, rat
Aplicação
flow cytometry
western blot
Anti-KV1.3 antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
immunofluorescence

immunohistochemistry
Anti-phospho-Kv1.3/KCNA3 (pTyr135) antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-KCNA3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
Anti-Potassium Channel Kv1.3 Antibody, Chemicon®, from rabbit,
Reatividade de espécies
human, mouse, rat
Aplicação
immunohistochemistry
western blot

Small Molecule - Blocker

Número do produto
Descrição
Espécies
Charybdotoxin, ≥90% (HPLC),
Espécies
mouse, rat, human
Guanidina, for molecular biology, ≥99%,
Espécies
human
Guanidina, ≥98%,
Espécies
human
Guanidina, ≥99% (titration), organic base and chaeotropic agent,
Espécies
human
Guanidina, ,
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human KCNA3,
Espécies
human