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Merck

CTCF

CCCTC-binding factor (zinc finger protein)

Sinônimos:
Espécies:
ID UniProtKB:
ID do gene:
  • Human(10664) Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13018) CCCTC-binding factor
  • Rat(83726) CCCTC-binding factor (zinc finger protein)
  • domestic guinea pig(100732580) CCCTC-binding factor (zinc finger protein)
  • Domestic Rabbit(100350641) CCCTC-binding factor (zinc finger protein)
  • chicken(396274) CCCTC-binding factor (zinc finger protein)
  • naked mole-rat(101709585) CCCTC-binding factor (zinc finger protein)
  • Zebrafish(415104) CCCTC-binding factor (zinc finger protein)
  • domestic cat(101101354) CCCTC-binding factor (zinc finger protein)
  • sheep(101114297) CCCTC-binding factor (zinc finger protein)
  • cow(517097) CCCTC-binding factor (zinc finger protein)
  • Horse(100053363) CCCTC-binding factor (zinc finger protein)
  • dog(479684) CCCTC-binding factor (zinc finger protein)
  • fruit fly(38817) CG8591 gene product from transcript CG8591-RA

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-CTCF Antibody, serum, Upstate®,
Reatividade de espécies
canine, human, mouse, primate, rat
Aplicação
ChIP
western blot
Anti-CTCF antibody, clone 1B18, ZooMAb® Rabbit monoclonal, recombinant, expressed in HEK 293 cells,
Reatividade de espécies
human, mouse, rat
Aplicação
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-CTCF antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0304, purified immunoglobulin, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunofluorescence
immunohistochemistry

western blot
ChIPAb+ CTCF - ChIP Validated Antibody and Primer Set, clone 1.2.1.5.4, from mouse,
Reatividade de espécies
human
Aplicação
ChIP
ELISA

dot blot

immunohistochemistry

immunoprecipitation (IP)

multiplexing

western blot
Monoclonal Anti-CTCF antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0307, purified immunoglobulin, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunofluorescence
immunohistochemistry

western blot

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human CTCF,
Espécies
human
MISSION® esiRNA, targeting mouse Ctcf,
Espécies
mouse