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Majocchi granuloma in a pregnant woman.

Obstetrics and gynecology (2014-07-09)
Ruihua Wang, Yong Hu, Hongfeng Tang, Tangde Zhang
ABSTRACT

Majocchi granuloma is a cutaneous dermatophyte infection of the dermal and subcutaneous tissues characterized by chronic erythematous and indurated plaques, which are almost always the result of immunodeficiency and trauma. Disseminated dermatophyte Majocchi granuloma was diagnosed in a 19-year-old woman at 32 weeks of gestation and had no history of trauma or chronic illness. She was treated with topical antifungal medications until delivery, at which time systemic medications were started. The skin lesions resolved by the time of her 6-week postpartum visit. The altered immune state of pregnancy suggests that Majocchi granuloma should occur with some regularity in pregnancy. That this case is the second one described in the literature suggests that it may be underdiagnosed. Punch biopsy should be considered for diagnosis of unusual skin lesions during pregnancy.

MATERIALS
Product Number
Brand
Product Description

Supelco
Itraconazole solution, 2.0 mg/mL (Methanol with 1% 1M HCl), ampule of 1 mL, certified reference material, Cerilliant®
Sigma-Aldrich
Bifonazole, ≥98% (HPLC)
Sigma-Aldrich
Itraconazole, ≥98% (HPLC)
Bifonazole, European Pharmacopoeia (EP) Reference Standard
Supelco
Bifonazole, Pharmaceutical Secondary Standard; Certified Reference Material
Itraconazole for system suitability, European Pharmacopoeia (EP) Reference Standard
Bifonazole for system suitability, European Pharmacopoeia (EP) Reference Standard