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  • Sequential continuous flow processes for the oxidation of amines and azides by using HOF·MeCN.

Sequential continuous flow processes for the oxidation of amines and azides by using HOF·MeCN.

ChemSusChem (2011-12-16)
Christopher B McPake, Christopher B Murray, Graham Sandford
PMID22170755
ABSTRACT

The generation and use of the highly potent oxidising agent HOF·MeCN in a controlled single continuous flow process is described. Oxidations of amines and azides to corresponding nitrated systems by using fluorine gas, water and acetonitrile by sequential gas-liquid/liquid-liquid continuous flow procedures are reported.