- Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein.
Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein.
Organic letters (2013-04-05)
Mette T Petersen, Thomas E Nielsen
PMID23550830
ABSTRACT
A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provided a new entry for the total synthesis of the antileukemic natural product violacein.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Violacein from Janthinobacterium lividum, >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)