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Straightforward acid-catalyzed synthesis of pyrrolyldipyrromethenes.

Angewandte Chemie (International ed. in English) (2012-06-26)
Changjiang Yu, Lijuan Jiao, Xujun Tan, Jun Wang, Yajun Xu, Yangchun Wu, Gaosheng Yang, Zhaoyun Wang, Erhong Hao
ABSTRACT

Three for one: Pyrrolyldipyrromethenes having different functional groups were efficiently synthesized from POCl(3)-promoted condensations between 5-chloro-2-formylpyrrole or isoindole derivatives and suitable pyrrole or indole fragments through a novel nucleophilic aromatic substitution of the initially formed protonated azafulvene rings.

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Sigma-Aldrich
Phosphorus(V) oxychloride, ReagentPlus®, 99%