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Merck

Torticollis under cyclobenzaprine.

Pharmacology (2009-07-11)
Reinhard Reuss, Iris Reuter, Marek Jauss, Falko Fischer, Silke C Muller, Erwin Stolz
ABSTRACT

The muscle-relaxing 5-HT(2) receptor antagonist cyclobenzaprine is structurally closely related to amitriptyline. It is widely used to treat patients presenting with back pain and fibromyalgia. Very rarely cyclobenzaprine toxicity can result in extrapyramidal symptoms, but occurrence of torticollis has not been reported so far. We report on a patient presenting with torticollis and myoclonic movements after treatment with cyclobenzaprine, who was successfully treated with intravenous biperiden. This case might be additional evidence for the necessity of appropriate dosage in case of liver impairment. Secondly there are possibly consequences as regards the therapy of motor side effects.

MATERIALS
Product Number
Brand
Product Description

Supelco
Cyclobenzaprine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Cyclobenzaprine hydrochloride, European Pharmacopoeia (EP) Reference Standard