- Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.
Bioorganic & medicinal chemistry letters (2008-11-11)
Naoto Kojima, Hiromi Hayashi, Satoshi Suzuki, Hiroaki Tominaga, Naoyoshi Maezaki, Tetsuaki Tanaka, Takao Yamori
PMID18993063
ABSTRACT
C4-Fluorinated analogues of solamin, an antitumor acetogenin, were synthesized and investigated for their antitumor activities against 39 tumor cell lines. C4-Fluorinated solamins showed more potent growth inhibitory activity against cancer cell lines than solamin.