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Dealkylation of phosphonate esters with chlorotrimethylsilane.

Nucleosides, nucleotides & nucleic acids (2001-09-21)
A J Gutierrez, E J Prisbe, J C Rohloff
PMID11563008
ABSTRACT

Chlorotrimethylsilane completely dealkylates phosphonate esters at elevated temperature in a sealed reaction vessel. These conditions are tolerated by a variety of functional groups and lead to high conversions of dimethyl, diethyl and diisopropyl phosphonates to their corresponding phosphonic acids.