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  • Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires.

Synthetic recovery of impulse propagation in myocardial infarction via silicon carbide semiconductive nanowires.

Nature communications (2022-01-12)
Paola Lagonegro, Stefano Rossi, Nicolò Salvarani, Francesco Paolo Lo Muzio, Giacomo Rozzi, Jessica Modica, Franca Bigi, Martina Quaretti, Giancarlo Salviati, Silvana Pinelli, Rossella Alinovi, Daniele Catalucci, Francesca D'Autilia, Ferdinando Gazza, Gianluigi Condorelli, Francesca Rossi, Michele Miragoli
ABSTRACT

Myocardial infarction causes 7.3 million deaths worldwide, mostly for fibrillation that electrically originates from the damaged areas of the left ventricle. Conventional cardiac bypass graft and percutaneous coronary interventions allow reperfusion of the downstream tissue but do not counteract the bioelectrical alteration originated from the infarct area. Genetic, cellular, and tissue engineering therapies are promising avenues but require days/months for permitting proper functional tissue regeneration. Here we engineered biocompatible silicon carbide semiconductive nanowires that synthetically couple, via membrane nanobridge formations, isolated beating cardiomyocytes over distance, restoring physiological cell-cell conductance, thereby permitting the synchronization of bioelectrical activity in otherwise uncoupled cells. Local in-situ multiple injections of nanowires in the left ventricular infarcted regions allow rapid reinstatement of impulse propagation across damaged areas and recover electrogram parameters and conduction velocity. Here we propose this nanomedical intervention as a strategy for reducing ventricular arrhythmia after acute myocardial infarction.

MATERIALS
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Product Description

Sigma-Aldrich
HL-1 Cardiac Muscle Cell Line, HL-1 Cardiac Muscle Cell Line has been extensively characterized and is a valuable model system to address questions of cardiac biology at the cellular & molecular levels.
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