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17884

Sigma-Aldrich

3-(2-Furoyl)quinoline-2-carboxaldehyde

≥95% (HPLC), suitable for fluorescence, BioReagent

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About This Item

Empirical Formula (Hill Notation):
C15H9NO3
CAS Number:
126769-01-5
Molecular Weight:
251.24
MDL number:
MFCD03427748
UNSPSC Code:
12171500
PubChem Substance ID:
57647686
NACRES:
NA.32

product line

BioReagent

Assay

≥95% (HPLC)

form

powder

solubility

methanol: soluble

fluorescence

λex 486 nm; λem ~600 nm in 0.1 M sodium borate pH 9.0 (after derivatization with glycine)

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

[H]C(=O)c1nc2ccccc2cc1C(=O)c3ccco3

InChI

1S/C15H9NO3/c17-9-13-11(15(18)14-6-3-7-19-14)8-10-4-1-2-5-12(10)16-13/h1-9H

InChI key

PNCHURHVMDRFTR-UHFFFAOYSA-N

General description

3-(2-Furoyl)quinoline-2-carboxaldehyde is a neutral fluorogenic probe for amines for the picomolar assay of proteins by capillary electrophoresis (CE).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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I H Lee et al.
Analytical chemistry, 70(21), 4546-4548 (1998-11-21)
We report a method for the analysis of picomolar concentration proteins using electrophoretically mediated microanalysis (EMMA) to label proteins on-column with a fluorogenic reagent. Labeling is followed by capillary zone electrophoresis separation and postcolumn detection based on laser-induced fluorescence. The
S Hu et al.
Journal of chromatography. A, 924(1-2), 369-375 (2001-08-28)
We report an electrophoretic mobility shift-based method to study the interactions between phospholipids and proteins by capillary electrophoresis with laser-induced fluorescence detection. A fluorogenic dye, 3-(2-furoyl)quinoline-2-carboxaldehyde (FQ), was used to label phosphatidylserine (PS). Then the FQ labeled PS (FQ-PS) was
Tingting Zhao et al.
Electrophoresis, 42(4), 350-359 (2020-11-29)
A quantitative method was developed for the direct identity confirmation and quantification of alendronate using CE-MS combined with a pH-assisted focusing technique, dynamic pH barrage junction focusing. A pH-induced variation in electrophoretic mobility led to online focusing of alendronate at
Melissa M Harwood et al.
Electrophoresis, 28(6), 932-937 (2007-02-20)
The composition of single MCF-7 breast cancer cells is characterized using 2-D CE. Individual MCF-7 cells were aspirated into a 30 mum inner diameter fused-silica capillary and lysed by contact with an SDS-containing buffer. Proteins and other primary amines were
Alexander V Stoyanov et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 780(2), 283-287 (2002-10-29)
Fluorogenic reagents are used for protein labeling when high-sensitivity fluorescence detection is required. Similar to traditional labeling with activated fluorescent dyes, such as fluorescein isothiocyanate, a fluorogenic reaction is expected to change the physical-chemical properties of proteins. Knowledge of these
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