BRCC3
BRCA1/BRCA2-containing complex, subunit 3
Synonyms:
BRCC36, C6.1A, CXorf53
Species:
Human BRCC3 (79184), Mouse Brcc3 (210766), Rat Brcc3 (316794), sheep BRCC3 (101114756), domestic cat BRCC3 (101096553), domestic guinea pig Brcc3 (100719736), dog BRCC3 (612642), cow BRCC3 (519513), chicken BRCC3 (422201), naked mole-rat Brcc3 (101719523)
UniProtKB ID:
Gene ID:
- Human(79184) Summary: This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]
- Mouse(210766) BRCA1/BRCA2-containing complex, subunit 3
- Rat(316794) BRCA1/BRCA2-containing complex, subunit 3
- sheep(101114756) BRCA1/BRCA2-containing complex, subunit 3
- domestic cat(101096553) BRCA1/BRCA2-containing complex, subunit 3
- domestic guinea pig(100719736) BRCA1/BRCA2-containing complex, subunit 3
- dog(612642) BRCA1/BRCA2-containing complex, subunit 3
- cow(519513) BRCA1/BRCA2-containing complex, subunit 3
- chicken(422201) BRCA1/BRCA2-containing complex, subunit 3
- naked mole-rat(101719523) BRCA1/BRCA2-containing complex, subunit 3
- Horse(100062237) BRCA1/BRCA2-containing complex, subunit 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-BRCC3 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-BRCC3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-BRCC3 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
esiRNA
Product Number
Description
Species