ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms:
ABL, JTK7, bcr/abl, c-ABL, p150, v-abl
Species:
Human ABL1 (25), Mouse Abl1 (11350), Rat Abl1 (311860), chicken ABL1 (417181), domestic cat ABL1 (101087622), Zebrafish abl1 (100000720), cow ABL1 (540876), naked mole-rat Abl1 (101724428), Horse ABL1 (100069715), domestic guinea pig Abl1 (100720976) ...More
UniProtKB ID:
Gene ID:
- Human(25) Summary: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]
- Mouse(11350) c-abl oncogene 1, non-receptor tyrosine kinase
- Rat(311860) c-abl oncogene 1, non-receptor tyrosine kinase
- chicken(417181) c-abl oncogene 1, non-receptor tyrosine kinase
- domestic cat(101087622) c-abl oncogene 1, non-receptor tyrosine kinase
- Zebrafish(100000720) c-abl oncogene 1, receptor tyrosine kinase
- cow(540876) c-abl oncogene 1, non-receptor tyrosine kinase
- naked mole-rat(101724428) c-abl oncogene 1, non-receptor tyrosine kinase
- Horse(100069715) c-abl oncogene 1, non-receptor tyrosine kinase
- domestic guinea pig(100720976) c-abl oncogene 1, non-receptor tyrosine kinase
- dog(491292) c-abl oncogene 1, non-receptor tyrosine kinase
- sheep(101122941) c-abl oncogene 1, non-receptor tyrosine kinase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ABL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Species Reactivity
human
Application
immunohistochemistry
Anti-ABL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-ABL1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-ABL antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-phospho-c-Abl (pTyr412) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
ABL1, active, His tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
ABL1 (27-end), active, His-tagged from mouse, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
mouse