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Merck

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Synonyms:
CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Species:
Human PIK3CA (5290), Mouse Pik3ca (18706), Rat Pik3ca (170911), sheep PIK3CA (101110015), chicken PIK3CA (424971), dog PIK3CA (488084), domestic guinea pig Pik3ca (100735084), naked mole-rat Pik3ca (101711934), domestic cat PIK3CA (101097413), cow PIK3CA (282306)
UniProtKB ID:
P42336, Q14CW1, Q99762
Gene ID:
  • Human(5290) Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]
  • Mouse(18706) phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • Rat(170911) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • sheep(101110015) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • chicken(424971) phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • dog(488084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic guinea pig(100735084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • naked mole-rat(101711934) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic cat(101097413) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • cow(282306) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

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Antibodies

Product Number
Description
Species Reactivity
Application
WH0005290M1
Monoclonal Anti-PIK3CA antibody produced in mouse, clone 3G3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
SAB2701957
Anti-PIK3CA antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry
western blot
SAB5700234
Anti-PIK3CA antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
SAB5700623
Anti-PIK3CA antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
ZRB1712
Anti-PI-3 kinase p110α Antibody, clone 1J4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
flow cytometry
immunohistochemistry
western blot

Cell Lines

Product Number
Description
Species
CLLS1003
DLD1 Cells PIK3CA +/-, ,
Species
human
CLLS1199
MCF10A CELLS PTEN (-/-) PIK3CA H1047R (+/-), ,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
PZ0235
PF-04691502, ≥98% (HPLC),
Species
human

Kits

Product Number
Description
Species
33-017
PI 3-Kinase HTRF® Assay; 1920 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 5 plates.,
Species
human
33-036
PI 3-Kinase HTRF® Assay; 10,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 10,000 wells.,
Species
human
33-04A
PI 3-Kinase 3-step HTRF® Assay, Everything you need to perform the PI3 Kinase 3-step HTRF assays (1920 wells).,
Species
human
33-047
PI 3-Kinase 3-step HTRF® Assay, The PI 3-Kinase 3-Step HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format.,
Species
human
33-037
PI 3-Kinase HTRF® Assay; 50,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 50,000 wells.,
Species
human

Proteins

Product Number
Description
Species
SRP0234
PI3 kinase [p110a(E545K)/p85a] Active human, recombinant, expressed in baculovirus infected insect cells, ≥55% (SDS-PAGE),
Species
human
SRP0235
PI3 kinase [p110a(H1047R)/p85a] Active human, recombinant, expressed in baculovirus infected insect cells, ≥60% (SDS-PAGE),
Species
human
14-782-M
PI 3-Kinase (p110α(E542K)/p85α), Human, 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E542K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.,
Species
human
SRP5319
PI3K (p110-α/p55-γ), active, His tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
14-783-M
PI3 Kinase (p110α(E545K)/p85α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E545K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
EHU231281
MISSION® esiRNA, targeting human PIK3CA (2),
Species
human
EMU053821
MISSION® esiRNA, targeting mouse Pik3ca,
Species
mouse
EHU039391
MISSION® esiRNA, targeting human PIK3CA,
Species
human