Skip to Content
Merck

Advances of Microneedles in Biomedical Applications.

Molecules (Basel, Switzerland) (2021-10-14)
Jie Xu, Danfeng Xu, Xuan Xuan, Huacheng He
ABSTRACT

A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Microneedle spring applicator set
Sigma-Aldrich
Microneedle template, 6x6 array, H 1000 μm, base size 250 μm, 1000µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 700 μm, base size 200 μm, 500 µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 500 μm, base size 150 μm, 500 µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 300 μm, base size 100 μm, 500 µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 500 μm, base size 200 μm, 500µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 800 μm, base size 200 μm, 500 µm pitch
Sigma-Aldrich
Microneedle loader set
Sigma-Aldrich
Microneedle template, 10x10 array, H 400 μm, base size 150 μm, 500 µm pitch
Sigma-Aldrich
Microneedle template, 6x6 array, H 1000 μm, base size 250 μm, 1500 µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 600 μm, base size 200 μm, 500µm pitch
Sigma-Aldrich
Microneedle template, 6x6 array, H 800 μm, base size 250 μm, 500µm pitch
Sigma-Aldrich
Microneedle template, 15x15 array, H 600 μm, base size 200 μm, 500µm pitch