Skip to Content
Merck

Microneedles-Based Transdermal Drug Delivery Systems: A Review.

Journal of biomedical nanotechnology (2018-03-02)
Ying Hao, Wei Li, XingLi Zhou, Fan Yang, ZhiYong Qian
ABSTRACT

A microneedle (MN) is a micron-sized needle with a height of 10-2000 μm and a width of 10-50 μm, which can penetrate through the epidermis layer to dermal tissue directly without pain. Microneedles are widely used in transdermal drug delivery systems (TDDS) because they are efficient, safe, convenient and painless. Morphologically, microneedles are divided into four types: solid microneedles, coated microneedles, dissolving microneedles, and hollow microneedles. Different types of microneedles play different roles in different research fields. Microneedles also have different characteristics and applications depending on the materials they are made from. In recent years, microneedles have frequently been used to deliver drugs, genes, proteins, RNA, and vaccines, and have achieved amazing therapeutic effect. Meanwhile, a variety of nano-carriers combined with microneedle delivery systems highlight the application of microneedles. The materials, types, and applications of the microneedles are summarized in this review. Overall, this review aims to serve as a foundational study of microneedles and hopes to promote their clinical application.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Microneedle spring applicator set
Sigma-Aldrich
Microneedle template, 10x10 array, H 700 μm, base size 200 μm, 500 µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 500 μm, base size 150 μm, 500 µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 300 μm, base size 100 μm, 500 µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 500 μm, base size 200 μm, 500µm pitch
Sigma-Aldrich
Microneedle template, 6x6 array, H 1000 μm, base size 250 μm, 1000µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 400 μm, base size 150 μm, 500 µm pitch
Sigma-Aldrich
Microneedle template, 6x6 array, H 1000 μm, base size 250 μm, 1500 µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 600 μm, base size 200 μm, 500µm pitch
Sigma-Aldrich
Microneedle template, 6x6 array, H 800 μm, base size 250 μm, 500µm pitch
Sigma-Aldrich
Microneedle loader set
Sigma-Aldrich
Microneedle template, 15x15 array, H 600 μm, base size 200 μm, 500µm pitch
Sigma-Aldrich
Microneedle template, 10x10 array, H 800 μm, base size 200 μm, 500 µm pitch