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Interactions of meningococci with endothelium.

Methods in molecular medicine (2001-01-01)
R S Heyderman, N J Klein
ABSTRACT

The vascular endothelium forms an essential barrier against invasion by Neisseria meningitidis from the nasopharynx into the circulation and against meningococcal invasion from the bloodstream into the brain. In previous chapters, there has therefore been considerable emphasis on techniques designed to investigate the mechanisms underlying meningococcal interactions with epithelial and endothelial surfaces. The vascular endothelium is also a major target for the host inflammatory response to meningococcal infection and indeed the ensuing endothelial damage underlies many of the clinical manifestations associated with this condition (1,2). For this reason, our work has focused on understanding the cellular and molecular consequences of meningococcalendothelial interactions.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Heparinase II from Flavobacterium heparinum, Lyophilized powder stabilized with approx. 25% bovine serum albumin, lyophilized powder, ≥100 units/mg protein (enzyme + BSA)
Sigma-Aldrich
Heparinase III from Flavobacterium heparinum, Lyophilized powder stabilized with approx. 25% (w/w) bovine serum albumin, ≥30 units/mg protein (enzyme + BSA)