Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

S0193

Sigma-Aldrich

SKF-86002

≥98% (HPLC), solid

Synonym(s):

6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C16H12N3FS
CAS Number:
72873-74-6
Molecular Weight:
297.35
MDL number:
MFCD00869367
UNSPSC Code:
12352200
PubChem Substance ID:
24724598
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

off-white

mp

189-190 °C (lit.)

solubility

DMSO: soluble >10 mg/mL

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4

InChI

1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

InChI key

YOELZIQOLWZLQC-UHFFFAOYSA-N

Gene Information

human ... IL1B(3553) , TNF(7124)
rat ... Alox5(25290)

Biochem/physiol Actions

p38 MAP kinase inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

M Pouliot et al.
Journal of immunology (Baltimore, Md. : 1950), 158(10), 4930-4937 (1997-05-15)
Prostaglandin endoperoxide synthase (PGHS; cyclooxygenase), the rate-limiting enzyme in the conversion of arachidonic acid to prostanoids, has two isoforms. PGHS-1 is constitutively expressed and involved in homeostasis, whereas PGHS-2 is inducible in monocytes in response to proinflammatory agents. Using freshly
Maria Tsirigotis et al.
PloS one, 3(5), e2130-e2130 (2008-05-08)
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood. Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p38MAPK and that the atypical PKC iota
B Schnyder et al.
The Biochemical journal, 331 ( Pt 2), 489-495 (1998-06-11)
Intracellular phosphorylations polymorphonuclear neutrophils are mediated by kinases, including mitogen activated-protein (MAP) kinases and phosphatidylinositol 3-kinase. In the present study we demonstrate their effector functions upon both ligation of cell-surface seven-transmembrane-spanning receptors by bacterial peptide formylmethionyl-leucylphenylalanine as well as in
Javier Hernández Losa et al.
Oncogene, 22(26), 3998-4006 (2003-06-25)
p38 MAPK has been implicated in the response to cancer therapy. To determine whether the activation of p38 MAPK could be specific to cancer therapy, we investigated the activation of p38 MAPK in response to several chemotherapeutic agents, such as
David J Diller et al.
Current topics in medicinal chemistry, 5(10), 953-965 (2005-09-24)
In the late 1970s and the early 1980s the initial p38 chemotype, the triaryl imidazoles, was discovered as an off-target effect during the development of cyclooxygenase and 5-lipoxygenase inhibitors long before the identity of the p38 kinase was known. During
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service