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377112

Sigma-Aldrich

3-Pyrroline

95%

Synonym(s):

2,5-Dihydropyrrole

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About This Item

Empirical Formula (Hill Notation):
C4H7N
CAS Number:
109-96-6
Molecular Weight:
69.11
Beilstein:
103173
EC Number:
203-723-1
MDL number:
MFCD00005213
UNSPSC Code:
12352100
PubChem Substance ID:
24863493
NACRES:
NA.22

Assay

95%

form

liquid

refractive index

n20/D 1.46 (lit.)

bp

90-91 °C/748 mmHg (lit.)

density

0.91 g/mL at 25 °C (lit.)

storage temp.

−20°C

SMILES string

C1NCC=C1

InChI

1S/C4H7N/c1-2-4-5-3-1/h1-2,5H,3-4H2

InChI key

JVQIKJMSUIMUDI-UHFFFAOYSA-N

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General description

3-Pyrroline is a heterocyclic building block. The excited state dynamics of 3-pyrroline by Hamiltonian model based on the vibronic coupling model has been investigated. Trifluoromethylated azomethine ylide is reported as precursor for the synthesis of 3-pyrroline building blocks. 3-Pyrrolines are reported as highly useful intermediates for the synthesis of functionalized pyrrolines, pyrrolidines and other natural products. Preparation of 3-pyrroline(2,5-dihydro-1H-pyrrole) from (Z)-1,4-dichloro-2-butene, via Delépine Reaction has been reported. It is formed as intermediate in the synthesis of N-(tert-butyloxycarbonyl)-3-pyrroline. Reaction of Me3Al and Me3Ga with 3-pyrroline is reported.
Various 3-pyrrolines (2,5-dihydropyrroles) have been synthesized by two-step reaction sequence of alkylation/alkylidene carbene CH-insertion reaction. Synthesis of 3-pyrroline has been reported by employing cis-1,4-dichloro-2-butene as starting reagent.

Application

3-Pyrroline is suitable for use in a study to investigate the core-level binding energies of simple unsaturated organic molecules bonded to the Si(001) surface by X-ray photoelectron spectroscopy (XPS). It may be used in the synthesis of renin inhibitors and vasodilators.

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Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H225,H302 + H332,H314

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Flam. Liq. 2 - Skin Corr. 1A

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

-0.4 °F - closed cup

Flash Point(C)

-18 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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A convenient route to 3-pyrroline utilizing the Delepine reaction.
Brandange S and Rodriguez B.
Synthesis, 4 , 347-348 (1988)
S H Rosenberg et al.
Journal of medicinal chemistry, 33(7), 1962-1969 (1990-07-01)
Incorporation of nonreactive polar functionalities at the C- and N-termini of renin inhibitors led to the development of a subnanomolar compound (21) with millimolar solubility. This inhibitor demonstrated excellent efficacy and a long duration of action upon intravenous administration to
A modified procedure for the preparation of 2, 5-dihydropyrrole (3-pyrroline).
Warmus JS, et al.
The Journal of Organic Chemistry, 58(1), 270-271 (1993)
S P Neville et al.
The journal of physical chemistry. A, 118(51), 11975-11986 (2014-09-16)
A model Hamiltonian based on the vibronic coupling model is developed to describe the excited state dynamics of 3-pyrroline. With the use of the method of improved relaxation in conjunction with the MCTDH wavepacket propagation algorithm, vibrational eigenstates corresponding to
An X-ray photoelectron spectroscopy study of the bonding of unsaturated organic molecules to the Si (001) surface.
Liu H and HamersRJ.
Surface Science, 416(3), 354-362 (1998)
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