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  • How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale.

How aluminum, an intracellular ROS generator promotes hepatic and neurological diseases: the metabolic tale.

Cell biology and toxicology (2013-03-07)
Sungwon Han, Joseph Lemire, Varun P Appanna, Christopher Auger, Zachary Castonguay, Vasu D Appanna
ABSTRACT

Metal pollutants are a global health risk due to their ability to contribute to a variety of diseases. Aluminum (Al), a ubiquitous environmental contaminant is implicated in anemia, osteomalacia, hepatic disorder, and neurological disorder. In this review, we outline how this intracellular generator of reactive oxygen species (ROS) triggers a metabolic shift towards lipogenesis in astrocytes and hepatocytes. This Al-evoked phenomenon is coupled to diminished mitochondrial activity, anerobiosis, and the channeling of α-ketoacids towards anti-oxidant defense. The resulting metabolic reconfiguration leads to fat accumulation and a reduction in ATP synthesis, characteristics that are common to numerous medical disorders. Hence, the ability of Al toxicity to create an oxidative environment promotes dysfunctional metabolic processes in astrocytes and hepatocytes. These molecular events triggered by Al-induced ROS production are the potential mediators of brain and liver disorders.

MATERIALS
Product Number
Brand
Product Description

Aluminum, IRMM®, certified reference material, 1.0 mm wire
Aluminum, IRMM®, certified reference material, 1.0 mm foil
Sigma-Aldrich
Aluminum, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis
Sigma-Aldrich
Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis
Sigma-Aldrich
Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis
Sigma-Aldrich
Aluminum, wire, diam. 1.0 mm, 99.999% trace metals basis
Sigma-Aldrich
Aluminum, granular, <1 mm, 99.7% trace metals basis
Aluminum, wire reel, 5m, diameter 2.0mm, as drawn, 99.999%
Aluminum, wire reel, 5m, diameter 0.25mm, as drawn, 99.999%
Aluminum, wire reel, 50m, diameter 0.25mm, hard, 99.99+%
Aluminum, wire reel, 5m, diameter 0.025mm, as drawn, 99.99+%
Aluminum, wire reel, 5m, diameter 0.025mm, as drawn, 99.0+%
Aluminum, honeycomb, 300x300mm, thickness 5mm, cell size 13mm, cell wall 0.1mm, core density 0.062g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, foam, 150x150mm, thickness 6.35mm, bulk density 0.2g/cm3, porosity 0.93, 2 pores/cm, aluminum 6101 grade, 98.5%
Aluminum, honeycomb, 600x600mm, thickness 20mm, cell size 3.2mm, cell wall 0.025mm, core density 0.072g/cm3, phenolic adhesive (resin), 99.5%
Aluminum, honeycomb, 300x300mm, thickness 13.9mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm3, phenolic adhesive (resin), facing skin aluminum 0.55mm, 99.9%
Aluminum, microleaf disks, 25mm, thinness 1.0μm, specific density 269.9μg/cm2, removable support, 99.999%
Aluminum, tube, 0.1m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, rod, 100mm, diameter 20.0mm, as drawn, 99.999%
Aluminum, rod, 500mm, diameter 15.0mm, as drawn, 99.999%
Aluminum, rod, 50mm, diameter 28mm, as drawn, 99.999%
Aluminum, tube, 2m coil, as drawn, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, 99.5%
Aluminum, insulated wire, 2m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%
Aluminum, tube, 1000mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%
Aluminum, sphere, 100pcs, diameter 2.5mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%
Aluminum, rod, 200mm, diameter 15.0mm, as drawn, 99.999%
Aluminum, rod, 500mm, diameter 5.0mm, as drawn, 99.999%
Aluminum, rod, 200mm, diameter 20.0mm, as drawn, 99.999%
Aluminum, rod, 200mm, diameter 12.7mm, 99%
Aluminum, tube, 100mm, outside diameter 0.6mm, inside diameter 0.3mm, wall thickness 0.15mm, as drawn, 99.5%