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V9263

Sigma-Aldrich

Monoclonal Anti-Vascular Cell Adhesion Molecule 1 antibody produced in mouse

~1 mg/mL, clone 1.4C3, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-VCAM-1

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About This Item

MDL number:
MFCD00240671
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1.4C3, monoclonal

form

buffered aqueous solution

mol wt

antigen 110 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 2-4 μg/mL using human tonsil tissue
immunohistochemistry (frozen sections): 2-4 μg/mL using human tonsil tissue
western blot: suitable

isotype

IgG1

UniProt accession no.

P19320

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VCAM1(7412)

General description

VCAM-1(Vascular Cell Adhesion Molecule-1) belongs to immunoglobulin-related gene superfamily of adhesion molecules and is a 110kD cell surface integral membrane glycoprotein. It is expressed mainly by cytokine-activated endothelium and plays a pivotal role in numerous immunological and inflammatory responses. Monoclonal anti-vascular cell adhesion molecule 1 antibody can be used in immunohistochemistry for formalin-fixed, paraffin-embedded tissue sections. Mouse anti-vascular cell adhesion molecule 1 antibody reacts specifically with human vascular cell adhesion molecule-1 (CD106 or INCAM-110).

Immunogen

stimulated HUVEC cells and mouse NS1 cells.

Application

Monoclonal anti-vascular cell adhesion molecule 1 antibody can be used in immunoblotting and western blotting.

Physical form

Solution in phosphate buffered saline containing 0.08% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Darren G Woodside et al.
Journal of immunology (Baltimore, Md. : 1950), 176(8), 5041-5049 (2006-04-06)
Cell adhesion mediated by the interaction between integrin alpha4beta1 and VCAM-1 is important in normal physiologic processes and in inflammatory and autoimmune disease. Numerous studies have mapped the alpha4beta1 binding sites in VCAM-1 that mediate cell adhesion; however, little is
A G Kumar et al.
Journal of immunology (Baltimore, Md. : 1950), 153(9), 4088-4098 (1994-11-01)
Vascular cell adhesion molecule-1 (VCAM-1) is a member of the Ig superfamily that shows increased expression in a number of pathologic conditions. The role of VCAM-1 in human disease remains undefined and murine models are being extensively studied to help
Amarylis C B A Wanschel et al.
Biomolecules, 11(1) (2021-01-13)
Endothelial dysfunction precedes atherosclerosis and is an independent predictor of cardiovascular events. Cholesterol levels and oxidative stress are key contributors to endothelial damage, whereas high levels of plasma high-density lipoproteins (HDL) could prevent it. Cholesteryl ester transfer protein (CETP) is

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