SML1851
RI(dl)-2
≥98% (HPLC)
Synonym(s):
N-Ethyl-4-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline
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About This Item
Empirical Formula (Hill Notation):
C19H17N3 · xC2HF3O2
CAS Number:
Molecular Weight:
287.36 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
, light orange to dark red
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.FC(F)(C(O)=O)F
Biochem/physiol Actions
RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 μM) without affecting its ssDNA-binding activity (IC50 >100 μM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC50 = 3.0 μM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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